Assay Detail
Binding
CHEMBL3871561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MPO chlorination activity (unknown origin) assessed as taurine chloramine formation after 5 mins in presence of H2O2/Cl- by HTS method
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.32 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347165 | — | — | 1 | 7.89 |
| CHEMBL3933129 | — | — | 1 | 7.27 |
| CHEMBL3929246 | — | — | 1 | 7.07 |
| CHEMBL3960919 | — | — | 1 | 6.57 |
| CHEMBL3920217 | — | — | 1 | 6.46 |
| CHEMBL3892909 | — | — | 1 | 6.44 |
| CHEMBL3910108 | — | — | 1 | 6.43 |
| CHEMBL3899797 | — | — | 1 | 6.43 |
| CHEMBL3980103 | — | — | 1 | 6.31 |
| CHEMBL1370773 | — | — | 1 | 6.30 |
| CHEMBL3919858 | — | — | 1 | 6.19 |
| CHEMBL3890813 | — | — | 1 | 6.18 |
| CHEMBL3980225 | — | — | 1 | 6.17 |
| CHEMBL3925807 | — | — | 1 | 6.16 |
| CHEMBL3981926 | — | — | 1 | 6.16 |
| CHEMBL3972038 | — | — | 1 | 5.94 |
| CHEMBL3953437 | — | — | 1 | 5.92 |
| CHEMBL3956919 | — | — | 1 | 5.85 |
| CHEMBL3947640 | — | — | 1 | 5.73 |
| CHEMBL3938850 | — | — | 1 | 5.60 |
| CHEMBL3901888 | — | — | 1 | 5.57 |
| CHEMBL3924941 | — | — | 1 | - |
| CHEMBL3929827 | — | — | 1 | - |
| CHEMBL3086915 | — | — | 1 | - |
| CHEMBL3086916 | — | — | 1 | - |
| CHEMBL3951169 | — | — | 1 | - |
| CHEMBL3932693 | — | — | 1 | - |
| CHEMBL3904692 | — | — | 1 | - |
| CHEMBL3943673 | — | — | 1 | - |
| CHEMBL162522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347165 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3933129 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3929246 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3960919 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3920217 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3892909 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3910108 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3899797 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3980103 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1370773 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3919858 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3890813 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3980225 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3925807 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3981926 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3972038 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL3953437 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3956919 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3947640 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL3938850 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3901888 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL162522 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3920922 | — | IC50 | - | — | - | |
| CHEMBL3911982 | — | IC50 | - | — | - | |
| CHEMBL3933465 | — | IC50 | - | — | - | |
| CHEMBL3221060 | — | IC50 | - | — | - | |
| CHEMBL1618762 | — | IC50 | - | — | - | |
| CHEMBL3970959 | — | IC50 | - | — | - | |
| CHEMBL3942433 | — | IC50 | - | — | - | |
| CHEMBL3938741 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3138959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3943673 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3904692 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3932693 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3951169 | — | IC50 | - | — | - | |
| CHEMBL3086916 | — | IC50 | - | — | - | |
| CHEMBL3086915 | — | IC50 | - | — | - | |
| CHEMBL3929827 | — | IC50 | - | — | - | |
| CHEMBL3924941 | — | IC50 | - | — | - |