Assay Detail
Binding
CHEMBL3871606
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Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.40 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3986609 | — | — | 1 | 7.82 |
| CHEMBL3954695 | — | — | 1 | 7.58 |
| CHEMBL3975342 | — | — | 1 | 7.55 |
| CHEMBL3983327 | — | — | 1 | 7.52 |
| CHEMBL3894492 | — | — | 1 | 7.51 |
| CHEMBL3974375 | — | — | 1 | 7.50 |
| CHEMBL3939365 | — | — | 1 | 7.32 |
| CHEMBL3923159 | — | — | 1 | 7.31 |
| CHEMBL3922175 | — | — | 1 | 7.19 |
| CHEMBL3935219 | — | — | 1 | 6.66 |
| CHEMBL3964280 | — | — | 1 | - |
| CHEMBL3946537 | — | — | 1 | - |
| CHEMBL3946005 | — | — | 1 | - |
| CHEMBL3953964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3986609 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3954695 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3975342 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3983327 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3894492 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3974375 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3939365 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3923159 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3922175 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3935219 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3964280 | — | IC50 | - | — | - | |
| CHEMBL3946537 | — | IC50 | - | — | - | |
| CHEMBL3946005 | — | IC50 | - | — | - | |
| CHEMBL3953964 | — | IC50 | > | 1000.0 | nM | - |