Assay Detail
Binding
CHEMBL3871901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit thrombin-induced platelet aggregation in rabbit platelet-rich plasma preincubated with rabbit liver microsomes for 4 hrs followed by addition to platelet
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.83 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539697 | DABIGATRAN ETEXILATE | 4.0 | 1 | 6.26 |
| CHEMBL3935798 | — | — | 1 | 5.71 |
| CHEMBL3960020 | — | — | 1 | 5.09 |
| CHEMBL3909953 | — | — | 1 | 4.60 |
| CHEMBL3979276 | — | — | 1 | 4.05 |
| CHEMBL3971094 | — | — | 1 | 4.04 |
| CHEMBL3899919 | — | — | 1 | 4.04 |
| CHEMBL3908646 | — | — | 1 | - |
| CHEMBL3889895 | — | — | 1 | - |
| CHEMBL3961893 | — | — | 1 | - |
| CHEMBL3890936 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539697 | DABIGATRAN ETEXILATE | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL3935798 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL3960020 | — | IC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL3909953 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL3979276 | — | IC50 | = | 88200.0 | nM | 4.05 |
| CHEMBL3971094 | — | IC50 | = | 91200.0 | nM | 4.04 |
| CHEMBL3899919 | — | IC50 | = | 91500.0 | nM | 4.04 |
| CHEMBL3908646 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3889895 | — | IC50 | = | 164000.0 | nM | - |
| CHEMBL3961893 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3890936 | — | IC50 | > | 1000000.0 | nM | - |