Assay Detail
Functional
CHEMBL3871966
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Antitrypanosomal activity against Trypanosoma brucei brucei Trypanosoma brucei brucei BS449 measured after 48 hrs using ATPlite-1 reagent by cell based luciferase reporter gene assay
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 4.94 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL790 | CHLORHEXIDINE | 4.0 | 2 | 6.49 |
| CHEMBL1651359 | — | — | 2 | 5.00 |
| CHEMBL200549 | — | — | 2 | 4.16 |
| CHEMBL344174 | — | — | 2 | 4.10 |
| CHEMBL200724 | — | — | 2 | - |
| CHEMBL200836 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL790 | CHLORHEXIDINE | EC50 | = | 321.0 | nM | 6.49 |
| CHEMBL1651359 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL200549 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL344174 | — | EC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL200724 | — | EC50 | = | 103992016.58 | nM | - |
| CHEMBL200836 | — | EC50 | = | 104472021.92 | nM | - |
| CHEMBL200549 | — | EC50 | = | 69823240.41 | nM | - |
| CHEMBL344174 | — | EC50 | = | 78704578.97 | nM | - |
| CHEMBL1651359 | — | EC50 | = | 9794899.85 | nM | - |
| CHEMBL790 | CHLORHEXIDINE | EC50 | = | 321366.05 | nM | - |
| CHEMBL200724 | — | EC50 | = | 104000.0 | nM | - |
| CHEMBL200836 | — | EC50 | = | 105000.0 | nM | - |