Assay Detail
Functional
CHEMBL3872098
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Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
20
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biotransformation of isofraxetin-6-O-β-d-glucopyranoside by Angelica sinensis (Oliv.) Diels callus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.49 | 6.12 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147741 | 3-FORMYLINDOLE | — | 2 | 6.12 |
| CHEMBL1235570 | — | — | 2 | 5.99 |
| CHEMBL1795382 | — | — | 2 | 5.91 |
| CHEMBL1872292 | — | — | 2 | 4.98 |
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | 4.45 |
| CHEMBL3974951 | — | — | 1 | - |
| CHEMBL510091 | CLEOMISCOSIN A | — | 1 | - |
| CHEMBL3965038 | — | — | 1 | - |
| CHEMBL3966431 | — | — | 1 | - |
| CHEMBL347645 | — | — | 1 | - |
| CHEMBL3955298 | — | — | 1 | - |
| CHEMBL566 | URACIL | 3.0 | 1 | - |
| CHEMBL451518 | — | — | 1 | - |
| CHEMBL3894520 | — | — | 1 | - |
| CHEMBL1669433 | — | — | 1 | - |
| CHEMBL402435 | WUWEIZISU B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147741 | 3-FORMYLINDOLE | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1235570 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL1795382 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1872292 | — | IC50 | = | 10570.0 | nM | 4.98 |
| CHEMBL1434 | MINOCYCLINE | IC50 | = | 35820.0 | nM | 4.45 |
| CHEMBL3974951 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1795382 | — | Inhibition | - | % | - | |
| CHEMBL510091 | CLEOMISCOSIN A | IC50 | > | 100000.0 | nM | - |
| CHEMBL3965038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1872292 | — | Inhibition | - | % | - | |
| CHEMBL3966431 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL347645 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3955298 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1235570 | — | Inhibition | - | % | - | |
| CHEMBL147741 | 3-FORMYLINDOLE | Inhibition | - | % | - | |
| CHEMBL451518 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3894520 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1669433 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL402435 | WUWEIZISU B | IC50 | > | 100000.0 | nM | - |
| CHEMBL566 | URACIL | IC50 | > | 100000.0 | nM | - |