Assay Detail
Binding
CHEMBL3873256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen measured after 1 min by Dixon plot method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycogen phosphorylase, muscle form (CHEMBL4696) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.92 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770455 | — | — | 1 | 7.19 |
| CHEMBL3770514 | — | — | 1 | 6.65 |
| CHEMBL3936229 | — | — | 1 | - |
| CHEMBL3954904 | — | — | 1 | - |
| CHEMBL3921272 | — | — | 1 | - |
| CHEMBL3946226 | — | — | 1 | - |
| CHEMBL3968658 | — | — | 1 | - |
| CHEMBL3937338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770455 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL3770514 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL3936229 | — | Ki | - | — | - | |
| CHEMBL3954904 | — | Ki | - | — | - | |
| CHEMBL3921272 | — | Ki | - | — | - | |
| CHEMBL3946226 | — | Ki | - | — | - | |
| CHEMBL3968658 | — | Ki | - | — | - | |
| CHEMBL3937338 | — | Ki | - | — | - |