Assay Detail
Functional
CHEMBL3874665
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Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel carbazole sulfonamide derivatives of antitumor agent: Synthesis, antiproliferative activity and aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.89 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.30 |
| CHEMBL3939038 | — | — | 1 | 7.85 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.70 |
| CHEMBL3920027 | — | — | 1 | 7.44 |
| CHEMBL3921093 | — | — | 1 | 6.44 |
| CHEMBL3969560 | — | — | 1 | 6.38 |
| CHEMBL3928935 | — | — | 1 | 6.35 |
| CHEMBL230296 | — | — | 1 | 6.17 |
| CHEMBL3911076 | — | — | 1 | 6.16 |
| CHEMBL3956488 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3939038 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL61 | PODOFILOX | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3920027 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3921093 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3969560 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3928935 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL230296 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL3911076 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3956488 | — | IC50 | = | 870.0 | nM | 6.06 |