Assay Detail
Binding
CHEMBL3874758
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Inhibition of human recombinant carbonic anhydrase-1 preincubated for 6 hrs by stopped-flow CO2 hydration assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.62 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL3976024 | — | — | 1 | 6.11 |
| CHEMBL3984047 | — | — | 1 | 4.90 |
| CHEMBL1993421 | — | — | 1 | 4.86 |
| CHEMBL3914224 | — | — | 1 | - |
| CHEMBL421646 | BENZOYLENUREA | — | 1 | - |
| CHEMBL266540 | QUINAZOLINONE | — | 1 | - |
| CHEMBL3896854 | — | — | 1 | - |
| CHEMBL3960492 | — | — | 1 | - |
| CHEMBL3986431 | — | — | 1 | - |
| CHEMBL3956977 | — | — | 1 | - |
| CHEMBL3977549 | — | — | 1 | - |
| CHEMBL3928695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL3976024 | — | Ki | = | 783.0 | nM | 6.11 |
| CHEMBL3984047 | — | Ki | = | 12600.0 | nM | 4.90 |
| CHEMBL1993421 | — | Ki | = | 13750.0 | nM | 4.86 |
| CHEMBL3914224 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL421646 | BENZOYLENUREA | Ki | > | 500000.0 | nM | - |
| CHEMBL266540 | QUINAZOLINONE | Ki | > | 500000.0 | nM | - |
| CHEMBL3896854 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL3960492 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL3986431 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL3956977 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL3977549 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL3928695 | — | Ki | > | 500000.0 | nM | - |