Assay Detail
Functional
CHEMBL3874797
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Inhibition of LPS/INF-gamma-stimulated nitric oxide production in mouse RAW264.7 cells by Greiss method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship of the inhibitory effects of flavonoids on nitric oxide production in RAW264.7 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.55 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76426 | — | — | 1 | 4.77 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.77 |
| CHEMBL3933594 | — | — | 1 | 4.74 |
| CHEMBL90568 | DIOSMETIN | — | 1 | 4.49 |
| CHEMBL243664 | ACACETIN | — | 1 | 4.27 |
| CHEMBL3960030 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76426 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3933594 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL90568 | DIOSMETIN | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL243664 | ACACETIN | IC50 | = | 53700.0 | nM | 4.27 |
| CHEMBL3960030 | — | IC50 | = | 59300.0 | nM | 4.23 |