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Assay Detail

CHEMBL3874800

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Functional
Inhibition of LPS/INF-gamma-stimulated nitric oxide production in mouse RAW264.7 cells measured after 16 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Structure-activity relationship of the inhibitory effects of flavonoids on nitric oxide production in RAW264.7 cells.
Jiang WJ, Daikonya A, Ohkawara M, Nemoto T, Noritake R, Takamiya T, Kitanaka S, Iijima H.
Bioorg Med Chem (2017) 25 : 779 -788
PubMed 27955927 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.66 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL454320 TRICIN 1 5.10
CHEMBL1272251 1 4.85
CHEMBL3942556 1 4.85
CHEMBL28 APIGENIN 1 4.85
CHEMBL150 KAEMPFEROL 1.0 1 4.82
CHEMBL170405 ROBINETIN 1 4.38
CHEMBL9352 NARINGENIN 1 4.22
CHEMBL3958936 1 4.20
CHEMBL3901561 1 -
CHEMBL482975 1 -
CHEMBL9323 DIHYDROKAEMPFEROL 1 -
CHEMBL3961616 1 -
CHEMBL3892618 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL454320 TRICIN IC50 = 8000.0 nM 5.10
CHEMBL1272251 IC50 = 14000.0 nM 4.85
CHEMBL3942556 IC50 = 14000.0 nM 4.85
CHEMBL28 APIGENIN IC50 = 14000.0 nM 4.85
CHEMBL150 KAEMPFEROL IC50 = 15000.0 nM 4.82
CHEMBL170405 ROBINETIN IC50 = 42000.0 nM 4.38
CHEMBL9352 NARINGENIN IC50 = 60000.0 nM 4.22
CHEMBL3958936 IC50 = 63000.0 nM 4.20
CHEMBL3901561 IC50 > 100000.0 nM -
CHEMBL482975 IC50 > 100000.0 nM -
CHEMBL9323 DIHYDROKAEMPFEROL IC50 > 100000.0 nM -
CHEMBL3961616 IC50 > 100000.0 nM -
CHEMBL3892618 IC50 > 100000.0 nM -