Assay Detail
Functional
CHEMBL3874922
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Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.82 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.20 |
| CHEMBL3984882 | — | — | 1 | 5.80 |
| CHEMBL3925765 | — | — | 1 | 5.60 |
| CHEMBL3919863 | — | — | 1 | 5.27 |
| CHEMBL3956332 | — | — | 1 | 5.25 |
| CHEMBL3968288 | — | — | 1 | 5.15 |
| CHEMBL3910156 | — | — | 1 | 5.06 |
| CHEMBL3947645 | — | — | 1 | 5.06 |
| CHEMBL3958941 | — | — | 1 | 4.98 |
| CHEMBL3932530 | — | — | 1 | 4.91 |
| CHEMBL3962222 | — | — | 1 | 4.86 |
| CHEMBL3915081 | — | — | 1 | 4.84 |
| CHEMBL3889907 | — | — | 1 | 4.84 |
| CHEMBL3930347 | — | — | 1 | 4.78 |
| CHEMBL3961118 | — | — | 1 | 4.75 |
| CHEMBL3976811 | — | — | 1 | 4.73 |
| CHEMBL2441914 | — | — | 1 | 4.69 |
| CHEMBL3897158 | — | — | 1 | 4.66 |
| CHEMBL3930849 | — | — | 1 | 4.66 |
| CHEMBL3979293 | — | — | 1 | 4.62 |
| CHEMBL3906095 | — | — | 1 | 4.60 |
| CHEMBL3958339 | — | — | 1 | 4.58 |
| CHEMBL3892130 | — | — | 1 | 4.55 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 4.54 |
| CHEMBL2441913 | — | — | 1 | 4.52 |
| CHEMBL3957284 | — | — | 1 | 4.52 |
| CHEMBL3985964 | — | — | 1 | 4.48 |
| CHEMBL3950246 | — | — | 1 | 4.32 |
| CHEMBL2348318 | TYROSOL CAFFEATE | — | 1 | 4.27 |
| CHEMBL3895274 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3984882 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3925765 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3919863 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3956332 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3968288 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3910156 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3947645 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3958941 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL3932530 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3962222 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3915081 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3889907 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL3930347 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL3961118 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL3976811 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL2441914 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL3897158 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL3930849 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3979293 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL3906095 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL3958339 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL3892130 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL2441913 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL3957284 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL3985964 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL3950246 | — | IC50 | = | 48200.0 | nM | 4.32 |
| CHEMBL2348318 | TYROSOL CAFFEATE | IC50 | = | 53200.0 | nM | 4.27 |
| CHEMBL3895274 | — | IC50 | = | 77600.0 | nM | 4.11 |
| CHEMBL2441915 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL2441916 | — | IC50 | = | 153000.0 | nM | - |