Assay Detail
Binding
CHEMBL3874926
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FAAH in rat brain microsomes using N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide as substrate after 60 mins by fluorescence-based reversed phase HPLC analysis
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.15 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175854 | — | — | 1 | 8.54 |
| CHEMBL3897053 | — | — | 1 | 8.05 |
| CHEMBL3917532 | — | — | 1 | 8.00 |
| CHEMBL3906001 | — | — | 1 | 7.96 |
| CHEMBL3973827 | — | — | 1 | 7.96 |
| CHEMBL3924002 | — | — | 1 | 7.92 |
| CHEMBL3954141 | — | — | 1 | 7.92 |
| CHEMBL3935429 | — | — | 1 | 7.92 |
| CHEMBL3957353 | — | — | 1 | 7.89 |
| CHEMBL3932943 | — | — | 1 | 7.89 |
| CHEMBL3962880 | — | — | 1 | 7.85 |
| CHEMBL590142 | — | — | 1 | 7.82 |
| CHEMBL3933992 | — | — | 1 | 7.72 |
| CHEMBL3944384 | — | — | 1 | 7.68 |
| CHEMBL3936528 | — | — | 1 | 7.41 |
| CHEMBL3918133 | — | — | 1 | 7.37 |
| CHEMBL3976882 | — | — | 1 | 7.31 |
| CHEMBL3908582 | — | — | 1 | 7.28 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 7.22 |
| CHEMBL3968351 | — | — | 1 | 7.03 |
| CHEMBL3921983 | — | — | 1 | 7.00 |
| CHEMBL598974 | — | — | 1 | 6.39 |
| CHEMBL3986042 | — | — | 1 | 6.39 |
| CHEMBL590143 | — | — | 1 | 6.32 |
| CHEMBL3906192 | — | — | 1 | 6.21 |
| CHEMBL3960423 | — | — | 1 | 6.20 |
| CHEMBL592145 | — | — | 1 | 6.08 |
| CHEMBL3938779 | — | — | 1 | 5.80 |
| CHEMBL3951706 | — | — | 1 | 5.75 |
| CHEMBL603330 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175854 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3897053 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3917532 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3906001 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3973827 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3924002 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3954141 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3935429 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3957353 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3932943 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3962880 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL590142 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3933992 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3944384 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3936528 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3918133 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3976882 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3908582 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL184238 | URB-597 | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3968351 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3921983 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL598974 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3986042 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL590143 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3906192 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3960423 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL592145 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3938779 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3951706 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL603330 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3925106 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3936085 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3914980 | — | IC50 | > | 10000.0 | nM | - |