Assay Detail
Binding
CHEMBL3874982
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Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.15 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3919973 | — | — | 1 | 7.27 |
| CHEMBL3893026 | — | — | 1 | 6.92 |
| CHEMBL3953289 | — | — | 1 | 6.85 |
| CHEMBL3973034 | — | — | 1 | 6.54 |
| CHEMBL3891920 | — | — | 1 | 6.33 |
| CHEMBL3901994 | — | — | 1 | 5.96 |
| CHEMBL3947837 | — | — | 1 | 5.52 |
| CHEMBL3937916 | — | — | 1 | 5.40 |
| CHEMBL3954140 | — | — | 1 | 5.38 |
| CHEMBL3977361 | — | — | 1 | 5.28 |
| CHEMBL3920891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3919973 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3893026 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3953289 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3973034 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3891920 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3901994 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3947837 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3937916 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3954140 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3977361 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3920891 | — | EC50 | > | 10000.0 | nM | - |