Assay Detail
Binding
CHEMBL3875255
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Inhibition of human DNA topoisomerase 2alpha-mediated decatenation of kinetoplast DNA after 60 mins by agarose gel electrophoresis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.70 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.52 |
| CHEMBL3883611 | — | — | 1 | 5.29 |
| CHEMBL3884560 | — | — | 1 | 4.95 |
| CHEMBL3883967 | — | — | 1 | 4.86 |
| CHEMBL3885093 | — | — | 1 | 4.75 |
| CHEMBL3885280 | — | — | 1 | 4.71 |
| CHEMBL3883774 | — | — | 1 | 4.71 |
| CHEMBL3884844 | — | — | 1 | 4.62 |
| CHEMBL3884562 | — | — | 1 | 4.46 |
| CHEMBL3883657 | — | — | 1 | 4.45 |
| CHEMBL3884650 | — | — | 1 | 4.06 |
| CHEMBL3883595 | — | — | 1 | 4.00 |
| CHEMBL3883370 | — | — | 1 | - |
| CHEMBL3883394 | — | — | 1 | - |
| CHEMBL3883473 | — | — | 1 | - |
| CHEMBL3885393 | — | — | 1 | - |
| CHEMBL3884054 | — | — | 1 | - |
| CHEMBL3883419 | — | — | 1 | - |
| CHEMBL3883499 | — | — | 1 | - |
| CHEMBL3883996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3883611 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL3884560 | — | IC50 | = | 11250.0 | nM | 4.95 |
| CHEMBL3883967 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3885093 | — | IC50 | = | 17750.0 | nM | 4.75 |
| CHEMBL3885280 | — | IC50 | = | 19440.0 | nM | 4.71 |
| CHEMBL3883774 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL3884844 | — | IC50 | = | 23770.0 | nM | 4.62 |
| CHEMBL3884562 | — | IC50 | = | 34330.0 | nM | 4.46 |
| CHEMBL3883657 | — | IC50 | = | 35650.0 | nM | 4.45 |
| CHEMBL3884650 | — | IC50 | = | 87580.0 | nM | 4.06 |
| CHEMBL3883595 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3883370 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3883394 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3883473 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3885393 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3884054 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3883419 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3883499 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3883996 | — | IC50 | > | 100000.0 | nM | - |