Assay Detail
Functional
CHEMBL3875263
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIα, G-quadruplex binding and cytotoxic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.12 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49442 | AMETANTRONE | 2.0 | 1 | 6.05 |
| CHEMBL3883419 | — | — | 1 | 5.69 |
| CHEMBL3883611 | — | — | 1 | 5.63 |
| CHEMBL3883774 | — | — | 1 | 5.53 |
| CHEMBL3884560 | — | — | 1 | 5.27 |
| CHEMBL3885093 | — | — | 1 | 5.22 |
| CHEMBL3884844 | — | — | 1 | 5.21 |
| CHEMBL3883967 | — | — | 1 | 5.18 |
| CHEMBL3883370 | — | — | 1 | 5.16 |
| CHEMBL3883657 | — | — | 1 | 5.14 |
| CHEMBL3884650 | — | — | 1 | 5.07 |
| CHEMBL3885280 | — | — | 1 | 4.99 |
| CHEMBL3884562 | — | — | 1 | 4.95 |
| CHEMBL3883996 | — | — | 1 | 4.70 |
| CHEMBL3883394 | — | — | 1 | 4.60 |
| CHEMBL3884054 | — | — | 1 | 4.39 |
| CHEMBL3883473 | — | — | 1 | 4.31 |
| CHEMBL3883595 | — | — | 1 | - |
| CHEMBL3883499 | — | — | 1 | - |
| CHEMBL3885393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49442 | AMETANTRONE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3883419 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL3883611 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL3883774 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL3884560 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL3885093 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL3884844 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3883967 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL3883370 | — | IC50 | = | 6870.0 | nM | 5.16 |
| CHEMBL3883657 | — | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL3884650 | — | IC50 | = | 8520.0 | nM | 5.07 |
| CHEMBL3885280 | — | IC50 | = | 10280.0 | nM | 4.99 |
| CHEMBL3884562 | — | IC50 | = | 11130.0 | nM | 4.95 |
| CHEMBL3883996 | — | IC50 | = | 19830.0 | nM | 4.70 |
| CHEMBL3883394 | — | IC50 | = | 25380.0 | nM | 4.60 |
| CHEMBL3884054 | — | IC50 | = | 40880.0 | nM | 4.39 |
| CHEMBL3883473 | — | IC50 | = | 49060.0 | nM | 4.31 |
| CHEMBL3883595 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3883499 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3885393 | — | IC50 | > | 100000.0 | nM | - |