Assay Detail
Binding
CHEMBL3875277
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant AChE preincubated for 5 mins followed by acetylthiocholine iodide substrate addition measured after 5 mins by Ellman's method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.90 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3883432 | — | — | 1 | 8.89 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.22 |
| CHEMBL3884690 | — | — | 1 | 8.21 |
| CHEMBL3884618 | — | — | 1 | 8.01 |
| CHEMBL3885186 | — | — | 1 | 7.89 |
| CHEMBL3884858 | — | — | 1 | 7.74 |
| CHEMBL3884988 | — | — | 1 | 7.36 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3883432 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3884690 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3884618 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL3885186 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL3884858 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL3884988 | — | IC50 | = | 43.6 | nM | 7.36 |
| CHEMBL95 | TACRINE | IC50 | = | 131.0 | nM | 6.88 |