Assay Detail
Binding
CHEMBL3875503
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Binding affinity to human WDR5 by isothermal titration calorimetry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.56 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3884726 | — | — | 1 | 8.12 |
| CHEMBL3884329 | — | — | 1 | 7.87 |
| CHEMBL3885241 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3884726 | — | Kd | = | 7.5 | nM | 8.12 |
| CHEMBL3884329 | — | Kd | = | 13.6 | nM | 7.87 |
| CHEMBL3885241 | — | Kd | = | 202.0 | nM | 6.70 |