Assay Detail
Functional
CHEMBL3875605
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Growth inhibition of human CEM cells after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel urea and bis-urea primaquine derivatives with hydroxyphenyl or halogenphenyl substituents: Synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.68 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3884036 | — | — | 1 | 5.39 |
| CHEMBL3885179 | — | — | 1 | 5.16 |
| CHEMBL3884792 | — | — | 1 | 4.89 |
| CHEMBL3884635 | — | — | 1 | 4.85 |
| CHEMBL3884203 | — | — | 1 | 4.75 |
| CHEMBL3883226 | — | — | 1 | 4.72 |
| CHEMBL3884942 | — | — | 1 | 4.68 |
| CHEMBL3884737 | — | — | 1 | 4.66 |
| CHEMBL3883465 | — | — | 1 | 4.64 |
| CHEMBL3884516 | — | — | 1 | 4.64 |
| CHEMBL3885281 | — | — | 1 | 4.62 |
| CHEMBL3885248 | — | — | 1 | 4.58 |
| CHEMBL3884850 | — | — | 1 | 4.50 |
| CHEMBL3884615 | — | — | 1 | 4.09 |
| CHEMBL3884814 | — | — | 1 | 4.01 |
| CHEMBL3884548 | — | — | 1 | - |
| CHEMBL3885143 | — | — | 1 | - |
| CHEMBL3884268 | — | — | 1 | - |
| CHEMBL3884574 | — | — | 1 | - |
| CHEMBL3885376 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3884036 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3885179 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3884792 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3884635 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3884203 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3883226 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3884942 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3884737 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3883465 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3884516 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3885281 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3885248 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3884850 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3884615 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL3884814 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL3884548 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL3885143 | — | IC50 | = | 111000.0 | nM | - |
| CHEMBL3884268 | — | IC50 | = | 118000.0 | nM | - |
| CHEMBL3884574 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL3885376 | — | IC50 | = | 110000.0 | nM | - |