Assay Detail
Binding
CHEMBL3875643
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Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by fluorescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.91 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3885040 | — | — | 1 | 5.62 |
| CHEMBL3884872 | — | — | 1 | 5.51 |
| CHEMBL1222043 | — | — | 1 | 5.48 |
| CHEMBL3885443 | — | — | 1 | 5.11 |
| CHEMBL3883795 | — | — | 1 | 5.00 |
| CHEMBL3885188 | — | — | 1 | 4.94 |
| CHEMBL3884826 | — | — | 1 | 4.72 |
| CHEMBL3883522 | — | — | 1 | 4.71 |
| CHEMBL3884658 | — | — | 1 | 4.64 |
| CHEMBL3884852 | — | — | 1 | 4.58 |
| CHEMBL3884083 | — | — | 1 | 4.57 |
| CHEMBL3883400 | — | — | 1 | 4.50 |
| CHEMBL3885260 | — | — | 1 | 4.46 |
| CHEMBL3884603 | — | — | 1 | - |
| CHEMBL3883981 | — | — | 1 | - |
| CHEMBL3884346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3885040 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3884872 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1222043 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3885443 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3883795 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL3885188 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3884826 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3883522 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL3884658 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL3884852 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL3884083 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL3883400 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL3885260 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL3884603 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3883981 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3884346 | — | IC50 | > | 50000.0 | nM | - |