Glutathione hydrolase 1 proenzyme · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P19440. Use UniProt P19440 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P19440 as the stable identity anchor, then attach disease evidence before program review.
Glutathione hydrolase 1 proenzyme
Review this target as Glutathione hydrolase 1 proenzyme, mapped to UniProt P19440. Sequence length is 569 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutathione hydrolase 1 proenzyme as ChEMBL target CHEMBL5696, mapped to UniProt P19440. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Glutathione hydrolase 1 proenzyme is the right protein anchor across sources, using UniProt P19440 as the stable mapping.
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| Preferred Name | Glutathione hydrolase 1 proenzyme |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P19440 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutathione hydrolase 1 proenzyme |
| UniProt Accession | P19440 |
| Component Type | Protein |
| Sequence Length | 569 aa |
Glutathione hydrolase 1 proenzyme
Review this target as Glutathione hydrolase 1 proenzyme, mapped to UniProt P19440. Sequence length is 569 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL87796 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL5220943 | 8.27 | Ki | 5.4 | Preclinical |
| CHEMBL5286162 | 7.41 | IC50 | 39.0 | Preclinical |
| CHEMBL5219012 | 7.35 | Ki | 45.0 | Preclinical |
| CHEMBL3039733 | 6.49 | IC50 | 322.0 | Clinical |
| CHEMBL5400857 | 6.04 | Ki | 920.0 | Preclinical |
| CHEMBL3885040 | 5.62 | IC50 | 2400.0 | Preclinical |
| CHEMBL3884872 | 5.51 | IC50 | 3100.0 | Preclinical |
| CHEMBL1222043 | 5.48 | IC50 | 3300.0 | Preclinical |
| CHEMBL3885443 | 5.11 | IC50 | 7800.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 14 | 48 | 5.2 |
| cell-based format | 2 | 0 | — |
| assay format | 1 | 8 | 6.3 |