Compound Detail
CHEMBL5220943
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5220943 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SIAJRDWJYITZRU-DFWYDOINSA-N |
| Parent Compound | CHEMBL87796 |
| Active Moiety | CHEMBL87796 |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
146.9
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutathione hydrolase 1 proenzyme CHEMBL5696 | Ki | 8.27 | 7.935 | 5.4 | 2 |
| Unchecked CHEMBL612545 | Ki | 7.77 | 7.77 | 17.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutathione hydrolase 1 proenzyme | Ki | = | 5.4 | nM | 8.27 | Inhibition of human GGT1 transpeptidation in Pichia pastoris using L-GpNA as sub... | 36208545 |
| Unchecked | Ki | = | 17.0 | nM | 7.77 | Inhibition of bovine GGT1 transpeptidation using gamma-glutamyl-p-nitroanilide i... | 36208545 |
| Glutathione hydrolase 1 proenzyme | Ki | = | 25.0 | nM | 7.6 | Inhibition of human GGT1 expressed in Pichia pastoris assessed as inhibition of ... | 36208545 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36208545 | 10.1016/j.bmc.2022.116986 | Glutathione hydrolase 1 proenzyme | 2 |
| 36208545 | 10.1016/j.bmc.2022.116986 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine