Assay Detail
Binding
CHEMBL5217445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GGT1 expressed in Pichia pastoris assessed as inhibition of GSH hydrolysis measured by L-glutamate release assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.26 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5220943 | — | — | 1 | 7.60 |
| CHEMBL5219012 | — | — | 1 | 7.11 |
| CHEMBL5219273 | — | — | 1 | 4.06 |
| CHEMBL5220603 | — | — | 1 | - |
| CHEMBL5219218 | — | — | 1 | - |
| CHEMBL5219778 | — | — | 1 | - |
| CHEMBL5220006 | — | — | 1 | - |
| CHEMBL5218520 | — | — | 1 | - |
| CHEMBL5220724 | — | — | 1 | - |
| CHEMBL5219724 | — | — | 1 | - |
| CHEMBL5218489 | — | — | 1 | - |
| CHEMBL5218962 | — | — | 1 | - |
| CHEMBL5218792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5220943 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL5219012 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL5219273 | — | Ki | = | 87000.0 | nM | 4.06 |
| CHEMBL5220603 | — | Ki | = | 260000.0 | nM | - |
| CHEMBL5219218 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL5219778 | — | Ki | = | 2150000.0 | nM | - |
| CHEMBL5220006 | — | Ki | - | — | - | |
| CHEMBL5218520 | — | Ki | - | — | - | |
| CHEMBL5220724 | — | Ki | = | 356000.0 | nM | - |
| CHEMBL5219724 | — | Ki | = | 108000.0 | nM | - |
| CHEMBL5218489 | — | Ki | - | — | - | |
| CHEMBL5218962 | — | Ki | = | 508000.0 | nM | - |
| CHEMBL5218792 | — | Ki | - | — | - |