Compound Detail
CHEMBL5219273
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Basic Information
| ChEMBL ID | CHEMBL5219273 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JBISBMUZBNLAPG-SSDOTTSWSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
227.0
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 4.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutathione hydrolase 1 proenzyme CHEMBL5696 | Ki | 4.58 | 4.32 | 26000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutathione hydrolase 1 proenzyme | Ki | = | 26000.0 | nM | 4.58 | Inhibition of human GGT1 transpeptidation in Pichia pastoris using L-GpNA as sub... | 36208545 |
| Glutathione hydrolase 1 proenzyme | Ki | = | 87000.0 | nM | 4.06 | Inhibition of human GGT1 expressed in Pichia pastoris assessed as inhibition of ... | 36208545 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36208545 | 10.1016/j.bmc.2022.116986 | Glutathione hydrolase 1 proenzyme | 2 |
Data from ChEMBL 36 via Core Engine