Assay Detail
Functional
CHEMBL3875646
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Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.66 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3885040 | — | — | 1 | 5.12 |
| CHEMBL3884852 | — | — | 1 | 4.88 |
| CHEMBL3885260 | — | — | 1 | 4.83 |
| CHEMBL3884658 | — | — | 1 | 4.81 |
| CHEMBL1222043 | — | — | 1 | 4.64 |
| CHEMBL3884826 | — | — | 1 | 4.58 |
| CHEMBL3885188 | — | — | 1 | 4.53 |
| CHEMBL3884872 | — | — | 1 | 4.48 |
| CHEMBL3884083 | — | — | 1 | 4.46 |
| CHEMBL3883981 | — | — | 1 | 4.28 |
| CHEMBL3885443 | — | — | 1 | - |
| CHEMBL3883400 | — | — | 1 | - |
| CHEMBL3883522 | — | — | 1 | - |
| CHEMBL3883795 | — | — | 1 | - |
| CHEMBL3884603 | — | — | 1 | - |
| CHEMBL3884346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3885040 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3884852 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3885260 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL3884658 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1222043 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3884826 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL3885188 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL3884872 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL3884083 | — | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL3883981 | — | IC50 | = | 52260.0 | nM | 4.28 |
| CHEMBL3885443 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3883400 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3883522 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3883795 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3884603 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3884346 | — | IC50 | > | 50000.0 | nM | - |