Assay Detail
Binding
CHEMBL3875677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting analysis
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new 6-hydroxypyridazinone benzisoxazoles: Potential multi-receptor-targeting atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 7.15 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3884161 | — | — | 1 | 11.00 |
| CHEMBL3885003 | — | — | 1 | 10.70 |
| CHEMBL3883955 | — | — | 1 | 8.23 |
| CHEMBL3884325 | — | — | 1 | 8.05 |
| CHEMBL3885471 | — | — | 1 | 8.03 |
| CHEMBL3884183 | — | — | 1 | 7.80 |
| CHEMBL3884918 | — | — | 1 | 7.60 |
| CHEMBL3883603 | — | — | 1 | 7.47 |
| CHEMBL3884994 | — | — | 1 | 7.42 |
| CHEMBL3884034 | — | — | 1 | 7.36 |
| CHEMBL3885180 | — | — | 1 | 7.32 |
| CHEMBL3884874 | — | — | 1 | 7.28 |
| CHEMBL3883495 | — | — | 1 | 7.26 |
| CHEMBL3884209 | — | — | 1 | 7.25 |
| CHEMBL3883773 | — | — | 1 | 7.25 |
| CHEMBL3884619 | — | — | 1 | 7.24 |
| CHEMBL3884105 | — | — | 1 | 7.21 |
| CHEMBL3884820 | — | — | 1 | 7.19 |
| CHEMBL3884681 | — | — | 1 | 7.11 |
| CHEMBL3884733 | — | — | 1 | 7.05 |
| CHEMBL3883408 | — | — | 1 | 7.05 |
| CHEMBL3883557 | — | — | 1 | 7.05 |
| CHEMBL3885211 | — | — | 1 | 6.99 |
| CHEMBL3884138 | — | — | 1 | 6.93 |
| CHEMBL3883388 | — | — | 1 | 6.92 |
| CHEMBL3884066 | — | — | 1 | 6.89 |
| CHEMBL3883429 | — | — | 1 | 6.80 |
| CHEMBL3883960 | — | — | 1 | 6.78 |
| CHEMBL3884300 | — | — | 1 | 6.74 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3884161 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL3885003 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL3883955 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL3884325 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL3885471 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL3884183 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL3884918 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3883603 | — | Ki | = | 34.2 | nM | 7.47 |
| CHEMBL3884994 | — | Ki | = | 38.1 | nM | 7.42 |
| CHEMBL3884034 | — | Ki | = | 43.5 | nM | 7.36 |
| CHEMBL3885180 | — | Ki | = | 48.1 | nM | 7.32 |
| CHEMBL3884874 | — | Ki | = | 52.8 | nM | 7.28 |
| CHEMBL3883495 | — | Ki | = | 55.4 | nM | 7.26 |
| CHEMBL3884209 | — | Ki | = | 56.5 | nM | 7.25 |
| CHEMBL3883773 | — | Ki | = | 56.2 | nM | 7.25 |
| CHEMBL3884619 | — | Ki | = | 57.3 | nM | 7.24 |
| CHEMBL3884105 | — | Ki | = | 61.3 | nM | 7.21 |
| CHEMBL3884820 | — | Ki | = | 64.8 | nM | 7.19 |
| CHEMBL3884681 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL3883557 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL3884733 | — | Ki | = | 88.4 | nM | 7.05 |
| CHEMBL3883408 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL3885211 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL3884138 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL3883388 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL3884066 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL3883429 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL3883960 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL3884300 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL85 | RISPERIDONE | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL3885254 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL3884581 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL3884065 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL3883511 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL3883942 | — | Ki | = | 333.0 | nM | 6.48 |
| CHEMBL3885327 | — | Ki | = | 624.0 | nM | 6.21 |
| CHEMBL3885016 | — | Ki | = | 898.0 | nM | 6.05 |
| CHEMBL3884545 | — | Ki | = | 984.0 | nM | 6.01 |
| CHEMBL3884885 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL3885088 | — | Ki | = | 1254.0 | nM | 5.90 |
| CHEMBL3883484 | — | Ki | = | 5530.0 | nM | 5.26 |
| CHEMBL3885152 | — | Ki | > | 10000.0 | nM | - |