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Assay Detail

CHEMBL3875798

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human JR8 cells assessed as growth inhibition after 72 hrs by MTS assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type JR8
Confidence 1 — Organism
Curated By Autocuration

Publication

[1,2]Oxazolo[5,4-e]isoindoles as promising tubulin polymerization inhibitors.
Spanò V, Pennati M, Parrino B, Carbone A, Montalbano A, Lopergolo A, Zuco V, Cominetti D, Diana P, Cirrincione G, Zaffaroni N, Barraja P.
Eur J Med Chem (2016) 124 : 840 -851
PubMed 27643641 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.22 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3885009 1 6.64
CHEMBL3884079 1 6.20
CHEMBL3884742 1 6.07
CHEMBL3885050 1 6.02
CHEMBL3883803 1 5.29
CHEMBL3885349 1 5.04
CHEMBL3884710 1 4.79
CHEMBL3883353 1 4.72
CHEMBL3884124 1 4.23
CHEMBL3884340 1 4.22
CHEMBL3883975 1 4.21
CHEMBL3884059 1 -
CHEMBL3884632 1 -
CHEMBL3885028 1 -
CHEMBL3884308 1 -
CHEMBL3883466 1 -
CHEMBL3884698 1 -
CHEMBL3884167 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3885009 IC50 = 230.0 nM 6.64
CHEMBL3884079 IC50 = 630.0 nM 6.20
CHEMBL3884742 IC50 = 850.0 nM 6.07
CHEMBL3885050 IC50 = 960.0 nM 6.02
CHEMBL3883803 IC50 = 5140.0 nM 5.29
CHEMBL3885349 IC50 = 9150.0 nM 5.04
CHEMBL3884710 IC50 = 16210.0 nM 4.79
CHEMBL3883353 IC50 = 19160.0 nM 4.72
CHEMBL3884124 IC50 = 58370.0 nM 4.23
CHEMBL3884340 IC50 = 59550.0 nM 4.22
CHEMBL3883975 IC50 = 61550.0 nM 4.21
CHEMBL3884059 IC50 > 100000.0 nM -
CHEMBL3884632 IC50 > 100000.0 nM -
CHEMBL3885028 IC50 > 100000.0 nM -
CHEMBL3884308 IC50 > 100000.0 nM -
CHEMBL3883466 IC50 > 100000.0 nM -
CHEMBL3884698 IC50 > 100000.0 nM -
CHEMBL3884167 IC50 > 100000.0 nM -