Assay Detail
Binding
CHEMBL3875854
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CDK5/p25 using histone H1 as substrate after 30 mins in presence of [gamma-33 P] ATP by liquid scintillation counting analysis
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.65 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753668 | — | — | 1 | 6.89 |
| CHEMBL3883660 | — | — | 1 | 6.36 |
| CHEMBL3885431 | — | — | 1 | 6.34 |
| CHEMBL3884015 | — | — | 1 | 6.11 |
| CHEMBL3883639 | — | — | 1 | 6.10 |
| CHEMBL3883764 | — | — | 1 | 6.10 |
| CHEMBL3884932 | — | — | 1 | 6.03 |
| CHEMBL3884583 | — | — | 1 | 5.80 |
| CHEMBL3884861 | — | — | 1 | 5.35 |
| CHEMBL3884845 | — | — | 1 | 5.27 |
| CHEMBL3885328 | — | — | 1 | 5.25 |
| CHEMBL3885360 | — | — | 1 | 5.22 |
| CHEMBL3883820 | — | — | 1 | 5.22 |
| CHEMBL3885021 | — | — | 1 | 5.19 |
| CHEMBL3884821 | — | — | 1 | 5.19 |
| CHEMBL3883448 | — | — | 1 | 5.16 |
| CHEMBL3885335 | — | — | 1 | 5.10 |
| CHEMBL3884627 | — | — | 1 | 5.05 |
| CHEMBL3885316 | — | — | 1 | - |
| CHEMBL3883458 | — | — | 1 | - |
| CHEMBL3883414 | — | — | 1 | - |
| CHEMBL3883541 | — | — | 1 | - |
| CHEMBL3885036 | — | — | 1 | - |
| CHEMBL3883813 | — | — | 1 | - |
| CHEMBL3884031 | — | — | 1 | - |
| CHEMBL3885333 | — | — | 1 | - |
| CHEMBL3884570 | — | — | 1 | - |
| CHEMBL3884241 | — | — | 1 | - |
| CHEMBL3885092 | — | — | 1 | - |
| CHEMBL3884027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753668 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3883660 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3885431 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3884015 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3883639 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3883764 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3884932 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL3884583 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3884861 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3884845 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3885328 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3885360 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3883820 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3885021 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3884821 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3883448 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3885335 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3884627 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3753955 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3884113 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3885482 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3883580 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3885267 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL269538 | HARMINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL3883356 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3884764 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3885315 | — | IC50 | - | — | - | |
| CHEMBL3884250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3883943 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3885043 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3884086 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3751934 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3753970 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3754608 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3753782 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3884027 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3885092 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3884241 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3884570 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3885333 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3884031 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3883813 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3885036 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3883541 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3883414 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3883458 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3885316 | — | IC50 | > | 10000.0 | nM | - |