Compound Detail

CHEMBL3885328

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COc1ccc2c(c1)[nH]c1c3ccncc3cc(CN)c21

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL3885328
Phase	Preclinical
Structure Type	MOL
InChI Key	JIPWXCWXQYQCQS-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

277.3

MW (Da)

3.34

ALogP

HBA

HBD

63.9

PSA (Å²)

0.59

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 7 meas. best 6.57

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Dual specificity protein kinase CLK4 CHEMBL4203	IC50	6.57	6.57	270.0	1
Dual specificity protein kinase CLK1 CHEMBL4224	IC50	6.08	6.08	830.0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292	IC50	6.06	6.06	870.0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B CHEMBL5543	IC50	6.04	6.04	910.0	1
Dual specificity protein kinase CLK2 CHEMBL4225	IC50	5.8	5.8	1600.0	1
Cyclin-dependent kinase 5/CDK5 activator 1 CHEMBL1907600	IC50	5.25	5.25	5600.0	1
Dual specificity protein kinase CLK3 CHEMBL4226	IC50	5.16	5.16	7000.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Dual specificity protein kinase CLK4	IC50	=	270.0	nM	6.57	Inhibition of GST-tagged human recombinant CLK4 expressed in Escherichia coli us...	27676471
Dual specificity protein kinase CLK1	IC50	=	830.0	nM	6.08	Inhibition of GST-tagged human recombinant CLK1 expressed in Escherichia coli us...	27676471
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	IC50	=	870.0	nM	6.06	Inhibition of GST-tagged human recombinant DYRK1A expressed in Escherichia coli ...	27676471
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	IC50	=	910.0	nM	6.04	Inhibition of GST-tagged human recombinant DYRK1B expressed in Escherichia coli ...	27676471
Dual specificity protein kinase CLK2	IC50	=	1600.0	nM	5.8	Inhibition of GST-tagged human recombinant CLK2 expressed in Escherichia coli us...	27676471
Cyclin-dependent kinase 5/CDK5 activator 1	IC50	=	5600.0	nM	5.25	Inhibition of human recombinant CDK5/p25 using histone H1 as substrate after 30 ...	27676471
Dual specificity protein kinase CLK3	IC50	=	7000.0	nM	5.16	Inhibition of GST-tagged human recombinant CLK3 expressed in Escherichia coli us...	27676471

PubMed	DOI	Target Context	# Activities
27676471	10.1016/j.ejmech.2016.08.069	Unchecked	1
27676471	10.1016/j.ejmech.2016.08.069	Cyclin-dependent kinase 5/CDK5 activator 1	1
27676471	10.1016/j.ejmech.2016.08.069	Glycogen synthase kinase-3	1
27676471	10.1016/j.ejmech.2016.08.069	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	1
27676471	10.1016/j.ejmech.2016.08.069	Dual specificity protein kinase CLK1	1
27676471	10.1016/j.ejmech.2016.08.069	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	1
27676471	10.1016/j.ejmech.2016.08.069	Dual specificity protein kinase CLK2	1
27676471	10.1016/j.ejmech.2016.08.069	Dual specificity protein kinase CLK3	1
27676471	10.1016/j.ejmech.2016.08.069	Dual specificity protein kinase CLK4	1
27676471	10.1016/j.ejmech.2016.08.069	NON-PROTEIN TARGET	1

Data from ChEMBL 36 via Core Engine