Assay Detail

CHEMBL3876587

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ADMET

Inhibition of recombinant CYP2C19 (unknown origin)

ChEMBL ↗

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Target

Cytochrome P450 2C19 (CHEMBL3622) ↗

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Cytochrome P450 2C19 (CHEMBL3622) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 2C19

CHEMBL3622

Anchored from Assay target.

Protein identity Cytochrome P450 2C19

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cytochrome P450 2C19 (CHEMBL3622) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.

Higgins MA, Marcin LR, Christopher Zusi F, Gentles R, Ding M, Pearce BC, Easton A, Kostich WA, Seager MA, Bourin C, Bristow LJ, Johnson KA, Miller R, Hogan J, Whiterock V, Gulianello M, Ferrante M, Huang Y, Hendricson A, Alt A, Macor JE, Bronson JJ.
Bioorg Med Chem (2017) 25 : 496 -513
PubMed 27914948 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.21	6.21

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3885379	—	—	1	6.21

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3885379	—	IC50	=	620.0	nM	6.21