Assay Detail
Toxicity
CHEMBL3876823
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Cytotoxicity against human WI38 cells assessed as reduction in cell viability after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | WI-38 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of new coumarin hybrids and insight into their mode of antiproliferative action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.74 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3883642 | — | — | 1 | 5.48 |
| CHEMBL3884097 | — | — | 1 | 5.06 |
| CHEMBL3884683 | — | — | 1 | 5.02 |
| CHEMBL3885183 | — | — | 1 | 4.96 |
| CHEMBL3885135 | — | — | 1 | 4.48 |
| CHEMBL3883396 | — | — | 1 | 4.44 |
| CHEMBL3884849 | — | — | 1 | 4.32 |
| CHEMBL3883518 | — | — | 1 | 4.17 |
| CHEMBL3883545 | — | — | 1 | - |
| CHEMBL1462108 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3883642 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3884097 | — | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL3884683 | — | IC50 | = | 9550.0 | nM | 5.02 |
| CHEMBL3885183 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL3885135 | — | IC50 | = | 33090.0 | nM | 4.48 |
| CHEMBL3883396 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL3884849 | — | IC50 | = | 48400.0 | nM | 4.32 |
| CHEMBL3883518 | — | IC50 | = | 67700.0 | nM | 4.17 |
| CHEMBL3883545 | — | IC50 | = | 353600.0 | nM | - |
| CHEMBL1462108 | — | IC50 | = | 292700.0 | nM | - |