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Assay Detail

CHEMBL3877050

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against human HF19 cells assessed as reduction in cell viability after 48 hrs by WST1 assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type HF19
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy.
El-Naggar MH, Mira A, Abdel Bar FM, Shimizu K, Amer MM, Badria FA.
Bioorg Med Chem (2017) 25 : 1277 -1285
PubMed 28065501 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.10 4.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3884151 1 4.26
CHEMBL3883516 1 4.11
CHEMBL3884952 1 4.05
CHEMBL29292 UBENIMEX 2.0 1 4.05
CHEMBL3883635 1 4.01
CHEMBL3883608 1 -
CHEMBL1950582 1 -
CHEMBL3883497 1 -
CHEMBL3883439 1 -
CHEMBL3884745 1 -
CHEMBL3884753 1 -
CHEMBL3884773 1 -
CHEMBL3884202 1 -
CHEMBL3526544 1 -
CHEMBL3885118 1 -
CHEMBL25948 SHOGAOL 1 -
CHEMBL3884622 1 -
CHEMBL3884665 1 -
CHEMBL3885075 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3884151 IC50 = 54800.0 nM 4.26
CHEMBL3883516 IC50 = 77620.0 nM 4.11
CHEMBL3884952 IC50 = 88360.0 nM 4.05
CHEMBL29292 UBENIMEX IC50 = 89510.0 nM 4.05
CHEMBL3883635 IC50 = 97540.0 nM 4.01
CHEMBL3883608 IC50 > 100000.0 nM -
CHEMBL1950582 IC50 > 100000.0 nM -
CHEMBL3883497 IC50 > 100000.0 nM -
CHEMBL3883439 IC50 > 100000.0 nM -
CHEMBL3884745 IC50 > 100000.0 nM -
CHEMBL3884753 IC50 > 100000.0 nM -
CHEMBL3884773 IC50 > 100000.0 nM -
CHEMBL3884202 IC50 > 100000.0 nM -
CHEMBL3526544 IC50 > 100000.0 nM -
CHEMBL3885118 IC50 > 100000.0 nM -
CHEMBL25948 SHOGAOL IC50 > 100000.0 nM -
CHEMBL3884622 IC50 > 100000.0 nM -
CHEMBL3884665 IC50 > 100000.0 nM -
CHEMBL3885075 IC50 > 100000.0 nM -