Assay Detail
Functional
CHEMBL3877082
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 5 days by Coulter counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.65 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | 8.47 |
| CHEMBL3885342 | — | — | 1 | 5.75 |
| CHEMBL3581633 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3885342 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3581633 | — | IC50 | = | 1900.0 | nM | 5.72 |