Assay Detail
Binding
CHEMBL3877133
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Irreversible inhibition of MPO (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From Dynamic Combinatorial Chemistry to in Vivo Evaluation of Reversible and Irreversible Myeloperoxidase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.68 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276832 | HYDRALAZINE | 4.0 | 1 | 6.05 |
| CHEMBL64 | ISONIAZID | 4.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276832 | HYDRALAZINE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL64 | ISONIAZID | IC50 | = | 5000.0 | nM | 5.30 |