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Assay Detail

CHEMBL3877179

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to MET (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Hepatocyte growth factor receptor (CHEMBL3717)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Non-kinase targets of protein kinase inhibitors.
Munoz L.
Nat Rev Drug Discov (2017) 16 : 424 -440
PubMed 28280261 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 8.57 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL601719 CRIZOTINIB 4.0 1 9.70
CHEMBL1825141 1 7.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL601719 CRIZOTINIB Kd = 0.2 nM 9.70
CHEMBL1825141 Kd = 37.5 nM 7.43