Assay Detail
Functional
CHEMBL3877398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.01 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.92 |
| CHEMBL3917405 | — | — | 1 | 5.84 |
| CHEMBL2035187 | PACRITINIB | 4.0 | 1 | 5.61 |
| CHEMBL3961053 | — | — | 1 | 5.47 |
| CHEMBL3972157 | — | — | 1 | 5.46 |
| CHEMBL3942555 | — | — | 1 | 5.23 |
| CHEMBL3945293 | — | — | 1 | 5.19 |
| CHEMBL3951291 | — | — | 1 | 5.09 |
| CHEMBL3915689 | — | — | 1 | 5.06 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 4.98 |
| CHEMBL3893970 | — | — | 1 | 4.97 |
| CHEMBL3920872 | — | — | 1 | 4.92 |
| CHEMBL3980203 | — | — | 1 | 4.90 |
| CHEMBL3943650 | — | — | 1 | 4.77 |
| CHEMBL3892860 | — | — | 1 | 4.70 |
| CHEMBL3982857 | — | — | 1 | 4.67 |
| CHEMBL3911929 | — | — | 1 | 4.59 |
| CHEMBL3954183 | — | — | 1 | 4.34 |
| CHEMBL3981879 | — | — | 1 | 4.27 |
| CHEMBL3962918 | — | — | 1 | 4.27 |
| CHEMBL3952364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3917405 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL2035187 | PACRITINIB | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL3961053 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL3972157 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL3942555 | — | IC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL3945293 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL3951291 | — | IC50 | = | 8070.0 | nM | 5.09 |
| CHEMBL3915689 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL3893970 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL3920872 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3980203 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3943650 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL3892860 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL3982857 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL3911929 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL3954183 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3981879 | — | IC50 | = | 53500.0 | nM | 4.27 |
| CHEMBL3962918 | — | IC50 | = | 54200.0 | nM | 4.27 |
| CHEMBL3952364 | — | IC50 | > | 50000.0 | nM | - |