Assay Detail
Functional
CHEMBL3877399
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.31 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035187 | PACRITINIB | 4.0 | 1 | 6.06 |
| CHEMBL3961053 | — | — | 1 | 5.92 |
| CHEMBL3980203 | — | — | 1 | 5.85 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.73 |
| CHEMBL3952364 | — | — | 1 | 5.70 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.70 |
| CHEMBL3917405 | — | — | 1 | 5.65 |
| CHEMBL3951291 | — | — | 1 | 5.59 |
| CHEMBL3964125 | — | — | 1 | 5.57 |
| CHEMBL3915689 | — | — | 1 | 5.50 |
| CHEMBL3942555 | — | — | 1 | 5.44 |
| CHEMBL3920872 | — | — | 1 | 5.22 |
| CHEMBL3945293 | — | — | 1 | 5.21 |
| CHEMBL3943650 | — | — | 1 | 5.09 |
| CHEMBL3893970 | — | — | 1 | 5.09 |
| CHEMBL3962918 | — | — | 1 | 4.53 |
| CHEMBL3911929 | — | — | 1 | 4.44 |
| CHEMBL3892860 | — | — | 1 | 4.39 |
| CHEMBL3982857 | — | — | 1 | 4.23 |
| CHEMBL3981879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035187 | PACRITINIB | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3961053 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3980203 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL3952364 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3917405 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL3951291 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL3964125 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3915689 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3942555 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL3920872 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL3945293 | — | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL3943650 | — | IC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL3893970 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3962918 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL3911929 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3892860 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL3982857 | — | IC50 | = | 59200.0 | nM | 4.23 |
| CHEMBL3981879 | — | IC50 | = | 124000.0 | nM | - |