Assay Detail
Functional
CHEMBL3877400
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Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.33 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.07 |
| CHEMBL3924682 | — | — | 1 | 5.80 |
| CHEMBL3917405 | — | — | 1 | 5.77 |
| CHEMBL2035187 | PACRITINIB | 4.0 | 1 | 5.62 |
| CHEMBL3961053 | — | — | 1 | 5.55 |
| CHEMBL3915689 | — | — | 1 | 5.34 |
| CHEMBL3942555 | — | — | 1 | 5.34 |
| CHEMBL3951291 | — | — | 1 | 5.09 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.07 |
| CHEMBL3920872 | — | — | 1 | 5.06 |
| CHEMBL3980203 | — | — | 1 | 5.00 |
| CHEMBL3945293 | — | — | 1 | 5.00 |
| CHEMBL3943650 | — | — | 1 | 4.64 |
| CHEMBL3952364 | — | — | 1 | - |
| CHEMBL3933593 | — | — | 1 | - |
| CHEMBL3972157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3924682 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3917405 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2035187 | PACRITINIB | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL3961053 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL3915689 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL3942555 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL3951291 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3920872 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL3980203 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3945293 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3943650 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL3952364 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3933593 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3972157 | — | IC50 | > | 100000.0 | nM | - |