Assay Detail
Functional
CHEMBL3877401
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.45 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035187 | PACRITINIB | 4.0 | 1 | 6.54 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.19 |
| CHEMBL3917405 | — | — | 1 | 5.83 |
| CHEMBL3961053 | — | — | 1 | 5.78 |
| CHEMBL3942555 | — | — | 1 | 5.56 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.43 |
| CHEMBL3915689 | — | — | 1 | 5.42 |
| CHEMBL3951291 | — | — | 1 | 5.32 |
| CHEMBL3980203 | — | — | 1 | 5.10 |
| CHEMBL3945293 | — | — | 1 | 5.02 |
| CHEMBL3920872 | — | — | 1 | 4.70 |
| CHEMBL3943650 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035187 | PACRITINIB | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3917405 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL3961053 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL3942555 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3915689 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL3951291 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL3980203 | — | IC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL3945293 | — | IC50 | = | 9480.0 | nM | 5.02 |
| CHEMBL3920872 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3943650 | — | IC50 | = | 27700.0 | nM | 4.56 |