Assay Detail
Functional
CHEMBL3877434
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Antiproliferative activity against human NKYS cells after 48 hrs by CellTiter-Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NKYS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.89 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3917405 | — | — | 1 | 5.97 |
| CHEMBL2035187 | PACRITINIB | 4.0 | 1 | 5.80 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3917405 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL2035187 | PACRITINIB | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL98 | VORINOSTAT | IC50 | - | — | - |