Assay Detail
ADMET
CHEMBL3877437
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Antiproliferative activity against mouse TAMH cells after 24 hrs by CellTiter-Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | TAMH |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.21 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2035187 | PACRITINIB | 4.0 | 1 | 5.43 |
| CHEMBL3945293 | — | — | 1 | 5.28 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.11 |
| CHEMBL3917405 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2035187 | PACRITINIB | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL3945293 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL3917405 | — | IC50 | = | 9570.0 | nM | 5.02 |