Assay Detail
Functional
CHEMBL3877620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.75 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.70 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.96 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.28 |
| CHEMBL3941981 | — | — | 1 | 5.96 |
| CHEMBL3963630 | — | — | 1 | 5.82 |
| CHEMBL3987053 | — | — | 1 | 5.55 |
| CHEMBL3986314 | — | — | 1 | 5.51 |
| CHEMBL3909378 | — | — | 1 | 5.47 |
| CHEMBL3894046 | — | — | 1 | 5.43 |
| CHEMBL3968638 | — | — | 1 | 5.43 |
| CHEMBL3949710 | — | — | 1 | 5.36 |
| CHEMBL3978776 | — | — | 1 | 5.33 |
| CHEMBL3985210 | — | — | 1 | 5.22 |
| CHEMBL3931933 | — | — | 1 | 5.13 |
| CHEMBL3353767 | — | — | 1 | 5.11 |
| CHEMBL3904202 | — | — | 1 | - |
| CHEMBL3353779 | — | — | 1 | - |
| CHEMBL3353773 | — | — | 1 | - |
| CHEMBL3907260 | — | — | 1 | - |
| CHEMBL3353785 | — | — | 1 | - |
| CHEMBL3958368 | — | — | 1 | - |
| CHEMBL3959424 | — | — | 1 | - |
| CHEMBL3940946 | — | — | 1 | - |
| CHEMBL3970493 | — | — | 1 | - |
| CHEMBL3930152 | — | — | 1 | - |
| CHEMBL3946205 | — | — | 1 | - |
| CHEMBL3900373 | — | — | 1 | - |
| CHEMBL3982713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3941981 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3963630 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL3987053 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3986314 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL3909378 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL3894046 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL3968638 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL3949710 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL3978776 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3985210 | — | IC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL3931933 | — | IC50 | = | 7460.0 | nM | 5.13 |
| CHEMBL3353767 | — | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL3904202 | — | IC50 | - | — | - | |
| CHEMBL3353779 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3353773 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3907260 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3353785 | — | IC50 | - | — | - | |
| CHEMBL3958368 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3959424 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3940946 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3970493 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3930152 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3946205 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3900373 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3982713 | — | IC50 | > | 50000.0 | nM | - |