Assay Detail
Binding
CHEMBL3877902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BChE pretreated for 20 mins followed by butyrylthiocholine iodide substrate addition measured for 5 mins by Ellman's method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.31 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3960040 | — | — | 1 | 8.74 |
| CHEMBL3971112 | — | — | 1 | 7.89 |
| CHEMBL3919289 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3960040 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3971112 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3919289 | — | IC50 | = | 5000.0 | nM | 5.30 |