Assay Detail
Binding
CHEMBL3878029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HeLa cell membranes after 30 mins by TopCount liquid scintillation counting method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.34 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3938383 | — | — | 1 | 9.03 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.90 |
| CHEMBL3917316 | — | — | 1 | 8.81 |
| CHEMBL3901382 | — | — | 1 | 8.65 |
| CHEMBL3981480 | — | — | 1 | 8.52 |
| CHEMBL3929328 | — | — | 1 | 8.52 |
| CHEMBL3892434 | — | — | 1 | 8.30 |
| CHEMBL2234448 | — | — | 1 | 8.29 |
| CHEMBL3970754 | — | — | 1 | 7.64 |
| CHEMBL1963046 | — | — | 1 | 7.64 |
| CHEMBL1183249 | — | — | 1 | 7.43 |
| CHEMBL3911497 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3938383 | — | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL13647 | BMY-7378 | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL3917316 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL3901382 | — | Ki | = | 2.239 | nM | 8.65 |
| CHEMBL3981480 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL3929328 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL3892434 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL2234448 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL3970754 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL1963046 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL1183249 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL3911497 | — | Ki | > | 1000.0 | nM | - |