Assay Detail
Functional
CHEMBL3878191
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Cytotoxicity against human HCT116 cells measured after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Preparation of novel ring-A fused azole derivatives of betulin and evaluation of their cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.90 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3945549 | — | — | 1 | 5.85 |
| CHEMBL3928708 | — | — | 1 | 5.55 |
| CHEMBL3938858 | — | — | 1 | 5.29 |
| CHEMBL3931888 | — | — | 1 | 5.25 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.17 |
| CHEMBL3918517 | — | — | 1 | 4.84 |
| CHEMBL3904962 | — | — | 1 | 4.79 |
| CHEMBL3984811 | — | — | 1 | 4.72 |
| CHEMBL3903902 | — | — | 1 | 4.65 |
| CHEMBL3912189 | — | — | 1 | 4.53 |
| CHEMBL3967618 | — | — | 1 | 4.48 |
| CHEMBL469284 | BETULONE | — | 1 | 4.47 |
| CHEMBL3902040 | — | — | 1 | 4.08 |
| CHEMBL3964234 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3945549 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3928708 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL3938858 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL3931888 | — | IC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3918517 | — | IC50 | = | 14290.0 | nM | 4.84 |
| CHEMBL3904962 | — | IC50 | = | 16030.0 | nM | 4.79 |
| CHEMBL3984811 | — | IC50 | = | 19010.0 | nM | 4.72 |
| CHEMBL3903902 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL3912189 | — | IC50 | = | 29280.0 | nM | 4.53 |
| CHEMBL3967618 | — | IC50 | = | 33450.0 | nM | 4.48 |
| CHEMBL469284 | BETULONE | IC50 | = | 34030.0 | nM | 4.47 |
| CHEMBL3902040 | — | IC50 | = | 83640.0 | nM | 4.08 |
| CHEMBL3964234 | — | IC50 | > | 100000.0 | nM | - |