Assay Detail
Functional
CHEMBL3878511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei 427 bloodstream forms assessed as parasitic growth inhibition after 48 hrs by alamar blue assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 6.06 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 9.05 |
| CHEMBL3978033 | — | — | 1 | 7.66 |
| CHEMBL3953659 | — | — | 1 | 7.41 |
| CHEMBL3969840 | — | — | 1 | 7.21 |
| CHEMBL3962406 | — | — | 1 | 7.09 |
| CHEMBL3938391 | — | — | 1 | 6.51 |
| CHEMBL3963464 | — | — | 1 | 6.46 |
| CHEMBL3920674 | — | — | 1 | 6.45 |
| CHEMBL3940296 | — | — | 1 | 6.27 |
| CHEMBL3902001 | — | — | 1 | 6.24 |
| CHEMBL3893388 | — | — | 1 | 6.00 |
| CHEMBL3925534 | — | — | 1 | 5.98 |
| CHEMBL3973685 | — | — | 1 | 5.86 |
| CHEMBL3968743 | — | — | 1 | 5.85 |
| CHEMBL3964014 | — | — | 1 | 5.81 |
| CHEMBL3982490 | — | — | 1 | 5.74 |
| CHEMBL3926341 | — | — | 1 | 5.71 |
| CHEMBL3957698 | — | — | 1 | 5.67 |
| CHEMBL3952954 | — | — | 1 | 5.49 |
| CHEMBL3942072 | — | — | 1 | 5.48 |
| CHEMBL3937165 | — | — | 1 | 5.42 |
| CHEMBL3970772 | — | — | 1 | 5.34 |
| CHEMBL3919401 | — | — | 1 | 5.05 |
| CHEMBL3982361 | — | — | 1 | 5.05 |
| CHEMBL3930540 | — | — | 1 | 5.04 |
| CHEMBL3965873 | — | — | 1 | 4.88 |
| CHEMBL3893578 | — | — | 1 | 4.82 |
| CHEMBL3935989 | — | — | 1 | - |
| CHEMBL3974359 | — | — | 1 | - |
| CHEMBL3944785 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3978033 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3953659 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3969840 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3962406 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3938391 | — | EC50 | = | 307.0 | nM | 6.51 |
| CHEMBL3963464 | — | EC50 | = | 343.0 | nM | 6.46 |
| CHEMBL3920674 | — | EC50 | = | 359.0 | nM | 6.45 |
| CHEMBL3940296 | — | EC50 | = | 539.0 | nM | 6.27 |
| CHEMBL3902001 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3893388 | — | EC50 | = | 999.0 | nM | 6.00 |
| CHEMBL3925534 | — | EC50 | = | 1058.0 | nM | 5.98 |
| CHEMBL3973685 | — | EC50 | = | 1397.0 | nM | 5.86 |
| CHEMBL3968743 | — | EC50 | = | 1399.0 | nM | 5.85 |
| CHEMBL3964014 | — | EC50 | = | 1539.0 | nM | 5.81 |
| CHEMBL3982490 | — | EC50 | = | 1813.0 | nM | 5.74 |
| CHEMBL3926341 | — | EC50 | = | 1952.0 | nM | 5.71 |
| CHEMBL3957698 | — | EC50 | = | 2154.0 | nM | 5.67 |
| CHEMBL3952954 | — | EC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL3942072 | — | EC50 | = | 3334.0 | nM | 5.48 |
| CHEMBL3937165 | — | EC50 | = | 3763.0 | nM | 5.42 |
| CHEMBL3970772 | — | EC50 | = | 4603.0 | nM | 5.34 |
| CHEMBL3919401 | — | EC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL3982361 | — | EC50 | = | 8802.0 | nM | 5.05 |
| CHEMBL3930540 | — | EC50 | = | 9013.0 | nM | 5.04 |
| CHEMBL3965873 | — | EC50 | = | 13311.0 | nM | 4.88 |
| CHEMBL3893578 | — | EC50 | = | 15263.0 | nM | 4.82 |
| CHEMBL3935989 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3974359 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3944785 | — | EC50 | > | 5000.0 | nM | - |