Assay Detail
Binding
CHEMBL3878788
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by microbeta liquid scintillation counting method
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.01 | 8.88 |
| Ki | 2 | 7.85 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | — | 2 | 8.88 |
| CHEMBL3948914 | — | — | 2 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481537 | PK-11195 | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL481537 | PK-11195 | Ki | = | 8.85 | nM | 8.05 |
| CHEMBL3948914 | — | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL3948914 | — | IC50 | = | 74.3 | nM | 7.13 |