Assay Detail
Binding
CHEMBL3879155
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Inhibition of Staphylococcus aureus 1199B NorA assessed as inhibition of ethidium bromide efflux measured after 5 mins by fluorometric method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Quinolone resistance protein NorA (CHEMBL5114) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Improved Potency of Indole-Based NorA Efflux Pump Inhibitors: From Serendipity toward Rational Design and Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.22 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3929187 | — | — | 1 | 5.75 |
| CHEMBL3956740 | — | — | 1 | 5.70 |
| CHEMBL3948087 | — | — | 1 | 5.42 |
| CHEMBL3955315 | — | — | 1 | 5.31 |
| CHEMBL3775105 | — | — | 1 | 5.22 |
| CHEMBL3775841 | — | — | 1 | 4.90 |
| CHEMBL3775507 | — | — | 1 | 4.77 |
| CHEMBL3945575 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3929187 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3956740 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL3948087 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL3955315 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL3775105 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3775841 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3775507 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL3945575 | — | IC50 | = | 19900.0 | nM | 4.70 |