Assay Detail
Binding
CHEMBL3879162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.73 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3897587 | — | — | 1 | 9.20 |
| CHEMBL3954476 | — | — | 1 | 9.10 |
| CHEMBL3906477 | — | — | 1 | 9.10 |
| CHEMBL3913807 | — | — | 1 | 9.10 |
| CHEMBL3970032 | — | — | 1 | 9.00 |
| CHEMBL3895863 | — | — | 1 | 8.90 |
| CHEMBL3964338 | — | — | 1 | 8.60 |
| CHEMBL3941507 | — | — | 1 | 8.50 |
| CHEMBL3916842 | — | — | 1 | 8.30 |
| CHEMBL3903742 | — | — | 1 | 8.30 |
| CHEMBL3921538 | — | — | 1 | 8.30 |
| CHEMBL2144065 | — | — | 1 | 8.20 |
| CHEMBL3986579 | — | — | 1 | 8.20 |
| CHEMBL3922787 | — | — | 1 | 8.10 |
| CHEMBL3897762 | — | — | 1 | 8.10 |
| CHEMBL3925845 | — | — | 1 | 7.90 |
| CHEMBL3931744 | — | — | 1 | 7.90 |
| CHEMBL3967137 | — | — | 1 | 7.70 |
| CHEMBL3912754 | — | — | 1 | 7.70 |
| CHEMBL3904310 | — | — | 1 | 7.70 |
| CHEMBL3966016 | — | — | 1 | 7.70 |
| CHEMBL3974512 | — | — | 1 | 7.60 |
| CHEMBL3934441 | — | — | 1 | 7.40 |
| CHEMBL1891894 | — | — | 1 | 7.20 |
| CHEMBL3929394 | — | — | 1 | 7.00 |
| CHEMBL3945819 | — | — | 1 | 6.80 |
| CHEMBL3907846 | — | — | 1 | 6.40 |
| CHEMBL3956962 | — | — | 1 | 5.80 |
| CHEMBL3894652 | — | — | 1 | 5.40 |
| CHEMBL3978360 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3897587 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL3954476 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL3906477 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL3913807 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL3970032 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3895863 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL3964338 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL3941507 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL3916842 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3903742 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3921538 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL2144065 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3986579 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3922787 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3897762 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3925845 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3931744 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3967137 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3912754 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3904310 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3966016 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3974512 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3934441 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1891894 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL3929394 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3945819 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL3907846 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3956962 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3894652 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL3978360 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL3983619 | — | IC50 | = | 6309.57 | nM | 5.20 |