Assay Detail
Binding
CHEMBL3879206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibition of CRP-XL-induced platelet aggregation preincubated for 5 mins followed by CRP-XL addition measured after 5 mins by turbidimetric method
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Glycoprotein VI Antagonists as Antithrombotics: Synthesis, Biological Evaluation, and Molecular Modeling Studies on 2,3-Disubstituted Tetrahydropyrido(3,4-b)indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.70 | 5.12 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308493 | — | — | 1 | 5.12 |
| CHEMBL3959435 | — | — | 2 | 4.27 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | - |
| CHEMBL2263356 | — | — | 1 | - |
| CHEMBL2263357 | S007-1558 (S) | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308493 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3959435 | — | IC50 | = | 53500.0 | nM | 4.27 |
| CHEMBL3959435 | — | Inhibition | - | % | - | |
| CHEMBL191 | LOSARTAN | IC50 | = | 158000.0 | nM | - |
| CHEMBL2263356 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2263357 | S007-1558 (S) | IC50 | = | 181400.0 | nM | - |