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Assay Detail

CHEMBL3879296

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Functional
Cytotoxicity against human HeLaS3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa S3
Confidence 1 — Organism
Curated By Autocuration

Publication

Determination of binding modes and binding constants for the complexes of 6H-pyrido[4,3-b]carbazole derivatives with DNA.
Shimazu A, Kawagoshi M, Takeda S, Kurasaki H, Kato A, Morii N, Sakai N, Konakahara T.
Bioorg Med Chem (2017) 25 : 1094 -1112
PubMed 28063783 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.31 6.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27112 1 6.03
CHEMBL3972677 1 5.98
CHEMBL3978097 1 5.92
CHEMBL123 ELLIPTECINE 1 5.68
CHEMBL3955340 1 5.62
CHEMBL3290745 1 5.54
CHEMBL3958267 1 5.18
CHEMBL3960544 1 5.12
CHEMBL3943103 1 4.82
CHEMBL3974431 1 4.50
CHEMBL3977754 1 4.02
CHEMBL3979734 1 -
CHEMBL3907158 1 -
CHEMBL3934017 1 -
CHEMBL3906034 1 -
CHEMBL3945002 1 -
CHEMBL3953712 1 -
CHEMBL3927109 1 -
CHEMBL3893146 1 -
CHEMBL3936064 1 -
CHEMBL3965937 1 -
CHEMBL3981431 1 -
CHEMBL3969337 1 -
CHEMBL26559 1 -
CHEMBL3982419 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27112 IC50 = 930.0 nM 6.03
CHEMBL3972677 IC50 = 1040.0 nM 5.98
CHEMBL3978097 IC50 = 1200.0 nM 5.92
CHEMBL123 ELLIPTECINE IC50 = 2100.0 nM 5.68
CHEMBL3955340 IC50 = 2400.0 nM 5.62
CHEMBL3290745 IC50 = 2900.0 nM 5.54
CHEMBL3958267 IC50 = 6580.0 nM 5.18
CHEMBL3960544 IC50 = 7600.0 nM 5.12
CHEMBL3943103 IC50 = 15000.0 nM 4.82
CHEMBL3974431 IC50 = 32000.0 nM 4.50
CHEMBL3977754 IC50 = 96000.0 nM 4.02
CHEMBL3979734 IC50 > 100000.0 nM -
CHEMBL3907158 IC50 > 22000.0 nM -
CHEMBL3934017 IC50 > 100000.0 nM -
CHEMBL3906034 IC50 - -
CHEMBL3945002 IC50 > 100000.0 nM -
CHEMBL3953712 IC50 > 100000.0 nM -
CHEMBL3927109 IC50 > 100000.0 nM -
CHEMBL3893146 IC50 > 100000.0 nM -
CHEMBL3936064 IC50 > 100000.0 nM -
CHEMBL3965937 IC50 - -
CHEMBL3981431 IC50 > 100000.0 nM -
CHEMBL3969337 IC50 - -
CHEMBL26559 IC50 - -
CHEMBL3982419 IC50 > 26000.0 nM -